Adele Sparavigna, Barbara Marzani, Giammaria Giuliani, Anna Benedusi
Beatrice Tenconi, Ileana De Ponti

The effectiveness of Lactobacillus rhamnosus T12 as food supplement was evaluated in a randomized double-blind placebo-controlled clinical trial in subjects with impaired production of sebum. In the study were enrolled 44 subjects randomly assigned to the active product or placebo intake, once a day for 2 months. The parameters were analysed by dermatological (visual
score of the main clinical signs of acne: comedones, papules, pustules, erythema, scaling, seborrhea, microcysts) and instrumental (evaluation of sebum, hydration, pH, evaporation, surface microrelief, sebum-regularizing properties and antioxidant comedolytic through the minimal erythema dose) evaluations before and after 1 and 2 months of treatments. The results obtained showed that Lactobacillus rhamnosus T12 intake induces, after 1 month, a significant reduction in sebum, into skin desquamation and a significant increase in hydration. The improvement showed by the active product are attributable to the regularization of sebum property, resulting in skin pH normalization, and to the comedolytic effect, after 2 months of treatment. In conclusion, the data obtained support the use of the L. rhamnosus T12 as food supplement in the treatment of impure skin and most probably also in skin diseases characterized by sebum production alteration such as seborrheic dermatitis and acne.